https://www.mangaupdates.com/series.html?id=3344 Description IS (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. This manga deals with issues concerning intersexual people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are. The series is consisted of cases, each dealing with different people - although some cases are much longer and more dramatic than others. The series eventually ends up being about Haru, an intersex child, in a touching coming-of-age story.